Dar-Fu Tai

　

Professor,  Bioorganic Chemistry

Phone: 03-8633579 (O) 03-8633580(Lab)

Fax: 03-866-3570  

Home Page

E-mail: dftai@mail.ndhu.edu.tw

Office hour: 10:00-12:00, Wednesday

National Dong Hwa University, Shou-Feng, Hualien, 974,  Taiwan

                                                   

  • Education

Ph.D., University of Pittsburg 1985 

　

  • Experience

Postdoctoral Fellow at Department of Chemistry, Massachusetts Institute of Technology 1985-1986,

Postdoctoral Fellow at Department of Applied Biological Science, Massachusetts Institute of Technology 1987,

Associate Research Fellow at Division of Biochemistry, Development Center for Biotechnology 1988-1990,

Associate Professor at Department of Food Engineering, Da-Yeh University 1990-1995,

Professor at Department of Food Engineering, Da-Yeh University 1996,

Professor at National Dong-Hwa University 1996-present

　

  • Research Interests

1)      Development of Artificial Enzymes.

2)      Surface Imprinting of Artificial Receptor on Chips for the Detection of Virus, Proteins, Peptides, and Small Molecules.

3)      Asymmetric Synthesis Using Molecular Imprinted Polymer as the Auxiliary.

4)      Understanding the Molecular Mechanisms Underlying the Formation of Supermolecules between Taste Receptor and Artificial Sweeteners.

5)      Peptide Related Drug Design and Synthesis.

6)      Discrimination of Human Plasma Proteins for Proteomic Research.

　

  • Selected Publications

    　

    1.          "Enhancement of the enantioselectivity of lipase OF catalyzed hydrolysis" Tetrahedron: Asymmetry, 12, 177-179 (2001).

    　

    2.          "Thiolsubtilisin acts as an acetyltransferase in organic solvents" FEBS Lett. 517, 24-26 (2002)

    　

    3.          "Purification of Candida rugosa lipase using agarose mercurial column" J. Chin. Chem. Soc., 49, 957-960 (2002).

    　

    4.          "Enzymatic Peptide synthesis: from the substrate point of view" Curr. Org. Chem. 515-554 (2003).

    　

    5.          "Development of immunochips for the detection of dengue viral antigens" Anal. Chim. Acta. 479, 117-123 (2003).

    　

    6.          "Bromelain catalyzed peptide synthesis in organic solvent" J. Chin. Chem. Soc., 50, 179-183 (2003).

    　

    7.          "Discrimination of peptides using a molecularly imprinted piezoelectric biosensor" Chem. Euro. J. 9, 5107-5110 (2003).

    　

    8.          Dar-Fu Tai,* Chung-Yin Lin, Tzong-Zeng Wu and Li-Kuang Chen (2005) “Recognition of Dengue Virus Protein Using Epitope-mediated Molecularly Imprinted film” Anal. Chem. 77, 5140 –5143.

     

    9.          Tzong-Zeng Wu, Chih-Cheng Su, Li-Kuang Chen, Hui-Hua Yang, Dar-Fu Tai, Kou-Cheng Peng (2005) “Piezoelectric immunochip for the detection of dengue fever in viremia phase” Biosens. Bioelectron, 21, 689-695.

     

    10.  Dar-Fu Tai,* Chung-Yin Lin, Tzong-Zeng, Jyh-Hsiung Huang and Pei-Yun Shu (2006) “Artificial receptors in serologic tests for the early diagnosis of dengue virus infection” Clin. Chem. 52,1486-1491.Cover article.SCI

     

    11.  Kuo-Haw Lu, Dar-Fu Tai* (2006). “Diagnostic aspects of human plasma proteins” Chemistry (in Chinese), 64, 119-128. 

     

    12.  Chi-Tai Chen and Dar-Fu Tai* (2006). "Sweeteners, sweet proteins and their taste receptor" Chemistry (in Chinese), 64, 129-140. 

     

    13.  Dar-Fu Tai* and Ai-Xuan Yeh (2006). "Enzymic synthesis of D-amino acids and their oligomers " Chemistry (in Chinese), 64, 377-386. 

     

    14.  Dar-Fu Tai*, and Yee-Fung Lin (2008) “Molecularly Imprinted Cavities Template the Macrocyclization of Tetrapeptides” Chem. Commun., 2008, 5598-5600.

     

    15.  Yee-Fung Lin, Shih-Ming Lee, Chi-Tai Chen, Kuo-Hau Lu, Dar-Fu Tai, (2009) “On-surface cyclization of tetrapeptides using molecularly imprinted polymers as non-covalent auxiliaries” J. Chin. Chem. Soc. 56, 127-134. 2009年中國化學會誌論文獎

     

    16.  Dar-Fu Tai*, Ming-Hong Jhang, Guan-Yu Chen, Sue-Chen Wang, Kuo-Hao Lu, Yu-Der Lee, and Hsin-Tzu Liu (2010) “Epitope-cavities generated by Molecularly Imprinted Films Measure the Coincident Response to Anthrax Protective Antigen and Its Segments” Anal. Chem. 82, in press.