Chinpiao Chen

Associate Professor,  Organic Chemistry

Phone: 03-8633597 (O) 03-8633598 (Lab)

Fax: 03-863-0475 (office) 03-863-3570 (Department office) 

Room:  D322 science building. 

Home Page   

E-mail: chinpiao@mail.ndhu.edu.tw

office hour: 14:00-16:00, Tuesday

National Dong Hwa University, Shou-Feng, Hualien, 974,  Taiwan

                                                   

  • Education

1975-1980：BS, National Taiwan Normal University

1988-1992：Ph. D. University of Pittsburgh (Advisor: Prof. Kozikowski, A. P.)

1988/8 – 1990/12：University of Pittsburgh, Pittsburgh, PA

1991/1 – 1993/1： Mayo Clinic - Jacksonville, Jacksonville, FL

  • Experience

1979/8-1988/7： Teacher, Junior High School, Keelung

1993/2-1995/4： Postdoctoral, Harvard University, (Prof. Kishi, Y.)

1995/6-1995/8： Researcher, Industry Research Institute

1995/9-2001/7： Associate Professor, Department of Medical Technology, Tzu Chi University

2001/8-2003/7： Assistant Professor, Department of Chemistry, National Dong Hwa University

2003/8-to date：Associate Professor, Department of Chemistry, National Dong Hwa University
　

  • Research Interests

Asymmetric Reaction

Drug Design and Synthesis 

New Reactions Investigation

  • Selected Publications

    　

    1. Chen, Y.-J.; Chen, C. 2006, The influence of electronic effects on the enantioselective reactions. Chemistry, 64, 1, 35-60.
    2. Huang, S.-T.; Hsei, I.-J.; Chen, C. 2006, Synthesis and Anticancer Evaluation of Bis(benzimidazoles), Bis(benzoxazoles), and Benzothiazoles. Bioorg. Med. Chem. 14, 17, 6105-6118.
    3. Xu, Y.-Z.; Chen, C. 2006, Synthesis of deuterium labelled standards of 5-methoxy-N,N-dimethyltryptamine (5-Meo-DMT). J. Labelled. Comp. Radiopharm. 49, 10, 897-902.

    4. Xu, Y.-Z.; Chen, C. 2006, Synthesis of deuterium labelled of phenethylamine derivatives. J. Labelled. Comp. Radiopharm. 49, 13, 1187-1200.

    5. Xu, Y.-Z.; Lin, H.-R.; Lua, C.-A; Chen, C. 2007, Syntheses of deuterium labeled 2,5-dimethoxyamphetamine (DMA), 4-bromo-2,5-dimethoxyamphetamine (DOB), and 4-methoxyamphetamine (PMA) as internal standards for quantitative analyses by GC-MS. J. Chin. Chem. Soc. 54, 2, 493-502.  

    6. Liu, S.-Y.; Lo, C.-T.; Chen, C.; Liu, M.-Y.; Chen, J.-H.; Peng K.-C.* 2007, Efficient Isolation of Anthraquinone-Derivatives from Trichoderma harzianum ETS 323. J. Biochem. Bioph. Meth. 70, 391-395.

    7. Shaikh, A. C.; Wang, Y.-Y.; Chen, C. 2007, Synthesis of deuterium labelled standards of (±)-DOM and (±)-MMDA. J. Labelled. Comp. Radiopharm. 50, 7, 660-665.

    8. Chen, Y.-J.; Chen, C. 2007, Enantioselective ring-opening reaction of meso-epoxide with ArSH catalyzed by a C2-symmetric chiral bipyridyldiol-titanium complex. Tetrahedron: Asymmetry 18, 11, 1313-1319.

    9. Leong, M.; Chen, C.; Shar, K. C.; Shiuan, D.* 2007, Selection and characterization of lipase abzyme from phage displayed antibody libraries. Biochem. Biophys. Res. Commun. 361, 567–573.

    10. Chen, Y.-J.; Chen, C. 2007, Synthesis of deuterium labelled standards of dihydroetorphine and etorphine. J. Labelled. Comp. Radiopharm. 50, 1143-1147.

    11. Wang, Y.-Y.; Chen, C. 2007, Synthesis of deuterium labelled tryptamine derivatives. J. Chin. Chem. Soc. 54, 5, 1363-1368.

    12. Wang, Y.-Y.; Chen, C. 2007, Synthesis of deuterium labelled standards of bufotenine (5-HO-DMT). J. Labelled. Comp. Radiopharm. 50, 14, 1262-1265.

    13. Chang, T.-C.; Chen, C. 2008, Chiral Aryl Pyridyl Alcohols as Enantioselective Catalysts in the Addition of Diethylzinc to Substituted Benzaldehydes. J. Chin. Chem. Soc. 55, 3, 606-615.

    14. Shaikh, A. C.; Chen, C. 2008, Synthesis of deuterium labeled zaleplon-d5 as an internal standard. J. Labelled. Comp. Radiopharm.51, 72-76.

    15. Hsua,T.-S.; Chen, C.; Lee, P.-T.; Chiu, S.-J.; Liua, H.-F.; Chao, J.-I. 2008, 7-Chloro-6-piperidin-1-yl-quinoline-5,8-dione (PT-262), a novel synthetic compound induces lung carcinoma cell death associated with inhibiting ERK and CDC2 phosphorylation via a p53-independent pathway. Cancer Chemoth. Pharm. 62, 799-808.

    16. You, Z.-Y.; Chen, Y.-J.; Wang, Y.-Y.; Chen, C. 2008, Synthesis of Deuterium Labelled Standards of 1-Benzylpiperazine, Fenetylline, Nicocodeine and Nicomorphine. J. Chin. Chem. Soc. 55, 3, 663-667.

    17. Chen, Y.-J.; Chen, C. 2008, Catalytic enantioselective Strecker-type reaction of phosphinoyl ketimines by bipyridyldiol derived chiral zirconium catalysts. Tetrahedron: Asymmetry, 19, 18, 2201-2209.

    18. Xu, Y.-Z.; Lin, H.-R. Lua, A.-C.; Chen, C. 2008, Determination of dimethoxyphenethylamine derivatives in urine by deuterium labeled internal standards. J. Serb. Chem. Soc. 73, 12, 1223-1233.

    19. Srimurugan, S.; Murugan, K.; Chen, C. 2009, A Facile Method for the Preparation of [2H3]-Sufentanil and Its Metabolites. Chem. Pharm. Bull. 57, 12, In press.

    20. Zheng, W.-W.; Hsieh, Y.-H.; Chiu, Y.-C.; Cai, S.-J.; Cheng, C.-L.; Chen, C. 2009, Organic functionalisation of ultradispersed nanodiamond: Synthesis and applications. J. Mater. Chem. In press.

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